T Cell Activation – AG Reinhard Obst

T cells are activated by antigen they recognize on the surface of dendritic cells in lymphoid tissues. We are interested in how the strength and length of antigen recognition affects T cell behavior. Since these parameters change over a wide range in different infections we have developed systems to change them at will to discover how T cells respond to briefly and chronically presented antigen.

© J. Greune / LMU

PD Dr. Reinhard Obst
Institut für Immunologie
Biomedizinisches Centrum München
Großhadernerstr. 9
DE- 82152 Planegg-Martinsried

+49 (0)89 2180 75631
reinhard.obst@med.uni-muenchen.de

Forschungsthemen

DFG: OB 150/7-1 Mechanisms of CD4+ T Cell Exhaustion by Persistent Antigen and Chronic Inflammation

Ausgewählte Publikationen

OrcID: https://orcid.org/0000-0002-4839-207X

Rosenlehner, T., Pennavaria, S., Akcabozan, B., Jahani, S., O'Neill, T. J., Krappmann, D., Straub, T., Kranich, J. and Obst, R. (2024 Oct 22) Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells. Sci Signal 2024. 17: eadi8753. DOI: 10.1126/scisignal.adi8753 (link)

Trefzer, A., Kadam, P., Wang, S. H., Pennavaria, S., Lober, B., Akçabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T. and Obst, R., Dynamic adoption of anergy by antigen-exhausted CD4+ T cells. Cell Rep 2021. 34: 108748. DOI: 10.1016/j.celrep.2021.108748

Obst, R. (2015). The timing of T cell priming and cycling. Front Immunol 6, 563.

Rabenstein, H., Behrendt, A.C., Ellwart, J.W., Naumann, R., Horsch, M., Beckers, J., and Obst, R. (2014). Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. J Immunol 192, 3507-3517.

Hoerr, I., Obst, R., Rammensee, H.G., and Jung, G. (2000). In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur J Immunol 30, 1-7.

Mitglieder AG Obst

NameTitelPositionEmail
Akcabozan, BatuhanMScDoctoral ResearcherBatuhan.Akcabozan@med.uni-muenchen.de
Obst, ReinhardPD Dr. rer. nat.Group Leaderreinhard.obst@med.uni-muenchen.de
Wieland, JosephineTATechnische AssistentinJosephine.Wieland@med.uni-muenchen.de